Things you should know before deciding for IVF / PGD
 
The rational for IVF treatment and gender selection

The following information are about technical limitation of gender selection by IVF program. Please read carefully.
  • The technology available now cannot separate sperm X and Y from each other completely since they are so similar and the only difference among them is chromosome content.
  • We have to let those sperms fertilized with eggs and developed to 8 cells stage or blastocyst stage embryo before we can perform biopsy procedure on those embryos.
  • The biopsy procedure will take one cell from 8-cells stage embryos or 3-5 cells from blastocyst stage embryos in order to check by FISH technic to tell whether each embryo has normal XX, or normal XY.
  • The FISH probe used will be able to detect chromosome X,Y,13,18 and 21 within the cell tested.

The chance of embryos tested may be as follow:

  • All female (XX) embryos
  • All male (XY) embryos
  • Male and female embryos with good quality both male and female
  • Male and female embryos with poor quality male embryos
  • Male and female embryos with poor quality female embryos
  • Male and female embryos with poor quality both gender
  • Embryos with abnormal chromosome 13,18 or 21
  • Embryos with abnormal sex chromosome eg. XO,XXY, XXYY

The purpose of this information is to give you an idea about gender selection procedure, limitation of technology, and possible outcome.

Fate of eggs and embryos in IVF & PGD program:

  • The goal of ovarian stimulation is to get around 8-12 eggs from stimulation and ovum pickup
  • From 8-12 eggs retrieved, after fertilization, 75%of eggs will turn into embryos: 6-8 embryos
  • From 6-8 embryos, 60 % will develop to blastocyst stage embryos.
  • From 3-4 good quality blastocysts, there should be one or two desire embryos for transfer.
  • The chance of success from transferring 1 or 2 good quality embryos is 35-40%

If you have any questions regarding the above information, please feel free to contact Dr. Viwat Chinpilas, Our Clinical Director through this form

 
PGD
PGD for Gender Selection
HLA Genotyping
Aneuploidy Screening
 
 
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