The rational for IVF treatment and gender selection
The following information are about technical limitation
of gender selection by IVF program. Please read
carefully.
- The technology available now cannot separate
sperm X and Y from each other completely since they
are so similar and the only difference among them is
chromosome content.
- We have to let those sperms fertilized with eggs
and developed to 8 cells stage or blastocyst stage
embryo before we can perform biopsy procedure on
those embryos.
- The biopsy procedure will take one cell from 8-cells
stage embryos or 3-5 cells from blastocyst stage
embryos in order to check by FISH technic to tell
whether each embryo has normal XX, or normal XY.
- The FISH probe used will be able to detect
chromosome X,Y,13,18 and 21 within the cell tested.
The chance of embryos tested may be as follow:
- All female (XX) embryos
- All male (XY) embryos
- Male and female embryos with good quality both
male and female
- Male and female embryos with poor quality male
embryos
- Male and female embryos with poor quality female
embryos
- Male and female embryos with poor quality both
gender
- Embryos with abnormal chromosome 13,18 or 21
- Embryos with abnormal sex chromosome eg. XO,XXY,
XXYY
The purpose of this information is to give you an
idea about gender selection procedure, limitation of
technology, and possible outcome.
Fate of eggs and embryos in IVF & PGD program:
- The goal of ovarian stimulation is to get around
8-12 eggs from stimulation and ovum pickup
- From 8-12 eggs retrieved, after fertilization,
75%of eggs will turn into embryos: 6-8 embryos
- From 6-8 embryos, 60 % will develop to
blastocyst stage embryos.
- From 3-4 good quality blastocysts, there should
be one or two desire embryos for transfer.
- The chance of success from transferring 1 or 2
good quality embryos is 35-40%
If you have any questions regarding the above
information, please feel free to contact Dr. Viwat
Chinpilas, Our Clinical Director through
this form |